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KLang Lab | Chemical Biology : Overview and News

Welcome to the Lang Group for Chemical Biology

The research of Kathrin Lang and her group is based in the interdisciplinary area between chemistry and biology. We are excited about developing tools to study and manipulate biological processes. We take a multidisciplinary approach and techniques typically span from chemical synthesis to protein engineering and cell biology. We are especially active in enabling and advancing approaches to expand the genetic code to incorporate non-​canonical amino acids beyond the 20 proteinogenic amino acids into proteins and in developing in vivo chemistries that are amenable to physiological conditions, as we are convinced that such a combined approach is ideally suited to address unmet challenges in studying and manipulating biological processes.

Expanding the Genetic Code - Beyond the 20 Natural Amino Acids

We develop methods to introduce non-canonical amino acids site-specifically into proteins in living systems.

What We Do

Bioorthogonal Reactions

We develop novel chemistries that do not only work in the test-tube but are selective and efficient within living cells.  

Crosslinking Reactions

We develop crosslinking reactions to study proteins interactions with other proteins and biomolecules in living cells.

Mimicking Post-Translational Modifications

We develop novel tools to understand ubiquitylation networks.