Publications
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Legend:
* denotes corresponding authors
1 denotes equally contributing authors
2024
V. Wanka1, M. Fottner1, M. Cigler and K. Lang*
Genetic Code Expansion Approaches to Decipher the Ubiquitin Code
Chem. Rev. 2024.
doi: external page 10.1021/acs.chemrev.4c00375
supported by ERC (Ubl-tool) and DFG (SFB1035, SPP1926)
M. Weyh1, M.J. Jokisch1, T.A. Nguyen, M. Fottner* and K. Lang*
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Nat. Chem. 2024, 16, 913–921.
doi: external page 10.1038/s41557-024-01500-5
supported by DFG (SFB1309, SFB1035), ERC (Ubl-tool) and ETH Zurich
D. Svatunek*1, A. Murnauer1, Z. Tan, K.N. Houk and K. Lang*
How cycloalkane fusion enhances the cycloaddition reactivity of dibenzocyclooctynes
Chem. Sci. 2024, 15, 2229-2235.
doi: external page 10.1039/d3sc05789e
supported by DFG (SFB1035, SPP1926) and ETH Zurich
2023
A. Markos1, M. Biedermann1, J. Heimgärtner, A. Schmitt, K. Lang and H. Wennemers*
Introducing Azomethine Imines to Chemical Biology: Bioorthogonal Reaction with Isonitriles
J. Am. Chem. Soc. 2023, 145, 19513–19517.
doi: external page 10.1021/jacs.3c07006
supported by SNF 188729, SNF 210357, DFG (SPP1962, SFB1035)
2022
Y.G. Mideksa, I. Aschenbrenner, A. Fux, D. Kaylani, C.A.M. Weiß, T.A. Nguyen, N.C. Bach, K. Lang, S.A. Sieber and M.J. Feige*
A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines
J. Biol. Chem. 2022, 298, 102677.
doi: external page 10.1016/j.jbc.2022.102677
supported by DFG (SPP 1623, SFB 1035)
M. Fottner, J. Heimgärtner1, M. Gantz1, R. Mühlhofer1, T. Nast-Kolb and K. Lang*
Site-specific protein labeling and generation of defined ubiquitin-protein conjugates using an asparaginyl endopeptidase
J. Am. Chem. Soc. 2022, 144, 13118–13126.
doi: external page 10.1021/jacs.2c02191
supported by ERC (Ubl-tool) and DFG (SPP 1926, SFB 1035)
T.A. Nguyen1, T. Gronauer1, T. Nast-Kolb, S. Sieber* and K. Lang*
Substrate profiling of mitochondrial caseinolytic protease P via a site-specific photocrosslinking approach
Angew. Chem. Int. Ed. 2022, 61, e202111085.
doi: external page 10.1002/anie.202111085
supported by DFG (SFB 1035, GRK 1721, SPP 1623)
2021
M. Fottner, M. Weyh, S. Gaussmann, D. Schwarz, M. Sattler and K. Lang*
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes
Nat. Commun. 2021, 12, 6515.
doi: external page 10.1038/s41467-021-26812-9
supported by ERC (Ubl-tool) and DFG (GRK 1721, SFB 1309)
S.L. Scinto, D.A. Bilodeau, R. Hincapie, W. Lee, S.S. Nguyen, M. Xu, C.W. am Ende, MG Finn, K. Lang, Q. Lin, J.P. Pezacki, J.A. Prescher, M.S. Robillard and J.M. Fox*
Bioorthogonal chemistry
Nat. Rev. Methods Primers 2021, 1, 30 (Review Article).
doi: external page 10.1038/s43586-021-00028-z
supported by DFG (SFB 1035, SPP 1623)
S. Tremel, Y. Ohashi, D.R. Morado, J. Bertram, O. Perisic, L.T.L. Brandt, M.K. von Wrisberg, Z.A. Chen, S.L. Maslen, O. Kovtun, M. Skehel J. Rappsilber, K. Lang, S. Munro*, J.A.G. Briggs* and R.L. Williams*
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
Nat. Commun. 2021, 12, 1564.
doi: external page 10.1038/s41467-021-21695-2
supported by DFG (SFB 1035)
M.D. Bartoschek, E. Ugur, T.A. Nguyen, G. Rodschinka, M. Wierer, K. Lang* and S. Bultmann*
Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells
Nucleic Acids Res. 2021, gkab132.
doi: external page 10.1093/nar/gkab132
supported by DFG (SPP 1623)
J. Du1, M.K. von Wrisberg1, B. Gulen, M. Stahl, C. Pett, C. Hedberg, K. Lang*, S. Schneider* and A. Itzen*
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Nat. Commun. 2021, 12, 460.
doi: external page 10.1038/s41467-020-20702-2
supported by DFG (SFB 1035), Excellence Initiative and EU Marie Curie COFUND Program
2020
M. Fottner, K. Lang*
Decorating proteins with LACE
Nat. Chem. 2020, 12, 980-982 (News and Views)
doi: external page 10.1038/s41557-020-00566-1
K. Krauskopf, K. Lang*
Increasing the chemical space of proteins in living cells via genetic code expansion
Curr. Opin. Chem. Biol., 2020, 58, 112-120 (Review article)
doi: external page 10.1016/j.cbpa.2020.07.012
supported by DFG (SFB 1035), Excellence Initiative and EU Marie Curie COFUND Program
A. Rehn1, J. Lawatscheck1, M.L. Jokisch, S.L. Mader, Q. Luo, F. Tippel, B. Blank, K. Richter, K. Lang, V.R.I. Kaila, J. Buchner*
A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
Nat. Commun., 2020, 11, 1219
doi: external page 10.1038/s41467-020-15048-8
supported by Excellence Initiative and EU Marie Curie COFUND Program
Y.G. Mideksa1, M. Fottner, S. Braus, C.A.M. Weiß, T.A. Nguyen, S. Meier, K. Lang, M.J. Feige*
Site-Specific Protein Labeling with Fluorophores as a Tool To Monitor Protein Turnover
ChemBioChem, 2020, 21, 1861-1867
doi: external page 10.1002/cbic.201900651
supported by DFG (SFB 1035) and EU Marie Curie COFUND program
2019
S.V. Mayer1, A. Murnauer1, M.K. von Wrisberg, M.L. Jokisch and K. Lang*
Photo-Induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes
Angew. Chem. Int Ed. 2019, 58, 15876-15882
doi: external page 10.1002/anie.201908209
K. Lang*
Installing Terminal-Alkyne Reactivity into Proteins in Engineered Bacteria
Biochemistry 2019, 58, 2703-2705 (Invited Viewpoint)
doi: external page 10.1021/acs.biochem.9b00392
M. Reille-Seroussi, S.V. Mayer, W. Dörner, K. Lang and H.D.D. Mootz*
Expanding the Genetic Code with a Lysine Derivative Bearing an Enzymatically Removable Phenylacetyl Group
Chem. Comm. 2019, 55, 4793-4796
doi: external page 10.1039/C9CC00475K
A. Hohl, Y.G. Mideksa, R. Karan, A. Akal, M. Vogler, M. Groll, M. Rueping, K. Lang, M.J. Feige, J. Eppinger*
Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells
Chembiochem 2019, 20, 1795-1798
doi: external page 10.1002/cbic.201900015
M. Fottner, A-D. Brunner, V. Bittl1, D. Horn-Ghetko1, A. Jussupow, V.R.I. Kaila, A. Bremm and K. Lang*
Site-specific ubiquitylation and SUMOylation using genetic code expansion and sortase
Nat. Chem. Biol. 2019, 15, 276-284
doi: external page 10.1038/s41589-019-0227-4
Highlighted in:
Amit Kumar Singh Gautam and Andreas Matouschek:
Decoding without the cipher (News and Views)
Nat Chem Biol. 2019, 15, 210
doi: external page 10.1038/s41589-019-0230-9
2018
T.A. Nguyen, M. Cigler, K. Lang*
Expanding the Genetic Code to Study Protein–Protein Interactions
Angew. Chem. Int. Ed. 2018, 57, 14350-14361
doi: external page 10.1002/anie.201805869
M. Cigler, T.A. Nguyen and K. Lang*
Genetic code expansion approaches to introduce artificial covalent bonds into proteins in vivo
In M.J. Feige (Ed), Oxidative Folding of Proteins, 2018, RSC Publishing
doi: external page 10.1039/9781788013253-00399
K. Lang*
Building Peptide Bonds in Haifa: The Seventh Chemical Protein Synthesis (CPS) Meeting
Chembiochem 2018, 19, 115-120 (Conference Report)
doi: external page 10.1002/cbic.201700606
2017
M. Cigler1, T.G. Müller1, D. Horn-Ghetko, M.K. von Wrisberg, M. Fottner, R. S. Goody, A. Itzen, M.P. Müller and K. Lang*
Proximity-triggered covalent stabilization of low affinity protein complexes in vitro and in vivo
Angew. Chem. Int. Ed. 2017, 56, 15737-15741
doi: external page 10.1002/anie.201706927
⇒ recommended by F1000Prime as being of special significance in its field
S. Mayer and K. Lang*,
Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology
Synthesis 2017, 49, 830-848 (Review Article)
doi: external page 10.1055/s-0036-1588682
K. Lang*
Biochemie 2016: Chemie bring Zellen im Innern zum Leuchten
Nachrichten aus der Chemie 2017, 65, 305-309 (invited report, in German)
doi: external page 10.1002/nadc.20174060650
2016
L. Jiao* and K. Lang*,
The 6th Sino-German Frontiers of Chemistry Symposium.
Chem. Asian J. 2016, 11, 3292 (Invited Conference Report)
doi: external page 10.1002/asia.201601538
S. Mayer and K. Lang*,
Chemie in lebenden Systemen
Nachrichten aus der Chemie 2017, 64 (3), 301-305 (Invited Report)
doi: external page 10.1002/nadc.20164047516
2015
T. Yu-Hsuan1, S. Essig1, J. James, K. Lang, and J.W. Chin*
Selective, rapid and optically switchable regulation of protein function in live mammalian cells
Nat. Chem. 2015, 7, 554-561
doi: external page 10.1038/nchem.2253
T. Machida, K. Lang, L. Xue, J.W. Chin and N. Winssinger*
Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne
Bionconjug. Chem. 2015, 26, 802-806
doi: external page 10.1021/acs.bioconjchem.5b00101
C. Uttamapinant, J.D. Howe, K. Lang, V. Beranek, L. Davis, M. Mahesh, N.P. Barry* and J.W. Chin*
Genetic code expansion enables live-cell and super-resolution of site-specifically labelled cellular proteins
J. Am. Chem. Soc 2015, 137, 4602-4605
doi: external page 10.1021/ja512838z
K. Lang*, L. Davis* and J.W. Chin
Genetic Encoding of Unnatural Amino Acids for Labeling Proteins
Methods Mol. Biol. 2015, 1266, 217-228.
doi: external page 10.1007/978-1-4939-2272-7_15
2014
K. Wang, A. Sachdeva, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace, R.A. Mehl and J.W. Chin*
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET
Nat. Chem. 2014, 6, 393-403
doi: external page 10.1038/nchem.1919
T.S Elliott1, F.M. Townsley1, A. Bianco1, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, K.S. Lilley and J.W. Chin*
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
Nat. Biotechnol. 2014, 32, 465-472
doi: external page 10.1038/nbt.2860
K. Lang*, J.W. Chin*
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
Chem. Rev. 2014, 114, 4764-4806
doi: external page 10.1021/cr400355w
D. Perez-Fernandez, D. Shcherbakov, T. Matt, N.C. Leong, I. Kudyba, S. Duscha, H. Boukari, R. Patak, S.R. Dubbaka, K. Lang, M. Meyer, R. Akbergenov, P. Freihofer, S. Vaddi, P. Thommes, V. Ramakrishnan, A. Vasella, E.C. Böttger
4'-O-substitutions determine selectivity of aminoglycoside antibiotics
Nat. Commun. 2014, 5, 3112
doi: external page 10.1038/ncomms4112
K. Lang*, J.W. Chin*
Bioorthogonal reactions for labeling proteins
ACS Chem. Biol. 2014, 9, 16-20 (In Focus Piece)
doi: external page 10.1021/cb4009292
2013
K. Lang* and J.W. Chin*
Fluorescence imaging: shining a light into live cells
Nat. Chem. 2013, 5, 81-82 (News and Views Article)
doi: external page 10.1038/nchem.1555
2012
A. Bianco, F. Townsley, S. Greiss, K. Lang, and J.W. Chin*
Expanding the genetic code of drosophila melanogaster
Nat. Chem. Biol. 2012, 8, 748-750
doi: external page 10.1038/nchembio.1043
T. Matt1, C.L. Ng1, K. Lang1, S.H. Sha1, R. Akbergenov1, D. Shcherbakov1, M. Meyer, S. Duscha, J. Xie, S.R. Dubbaka, D. Perez-Fernandez, A. Vasella, V. Ramakrishnan, J. Schacht, E.C. Böttger*
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
PNAS 2012, 109, 10984-10989
doi: external page 10.1073/pnas.1204073109
K. Lang, L. Davis, S. Wallace, M. Mahesh, D.J. Cox, M.L. Blackman, J.M. Fox, J.W. Chin*
Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions
J. Am. Chem. Soc. 2012, 134, 10317-10320
doi: external page 10.1021/ja302832g
K. Lang1, L. Davis1, J. Torres-Kolbus, C. Chou, A. Deiters*, J.W. Chin*
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
Nat. Chem. 2012, 5, 298-304
doi: external page 10.1038/nchem.1250
2011
S. Virdee, P.B. Kapadnis, T. Elliott, K. Lang, J. Madrzak, D.P. Nguyen, L. Riechmann, J.W. Chin*
Traceless and site-specific ubiquitination of recombinant proteins
J. Am. Chem. Soc. 2011, 133, 10708-10711
doi: external page 10.1021/ja202799r
2010
L. Ng1, K. Lang1, N. Meenan, A. Sharma, A. Kelley, C. Kleanthous*, V. Ramakrishnan*
Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3
Nat. Struct. Mol. Biol. 2010, 17, 1241-1246
doi: external page 10.1038/nsmb.1896
2009
U. Rieder, K. Lang, C. Kreutz, N. Polacek, R. Micura*
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers
ChemBioChem 2009, 10, 1141-1144
doi: external page 10.1002/cbic.200900155
V. Olieric, U. Rieder, K. Lang, A. Serganov, C. Schulze-Briese, R. Micura, P. Dumas, E. Ennifar*
A fast selenium derivatization strategy for crystallization and phasing of RNA structures
RNA 2009, 15, 707-715
doi: external page 10.1261/rna.1499309
2008
K. Lang and R. Micura*
The preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized RNA fragments
Nat. Protocols 2008, 3, 1457-1466
doi: external page 10.1038/nprot.2008.135
K. Lang, M.D. Erlacher, D.N. Wilson, R. Micura* and N. Polacek*
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis
Chemistry & Biology 2008, 15, 485-492
doi: external page 10.1016/j.chembiol.2008.03.014
S. Freisz, K. Lang, R. Micura, P. Dumas and E. Ennifar*
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA Dimerization Initiation Site
Angew. Chem. Int. Ed. 2008, 47, 4178-4181
doi: external page 10.1002/ange.200800726
2007
K. Lang, R. Rieder, and R. Micura*
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach
Nucleic Acids Res. 2007, 35, 5370-5378
doi: external page 10.1093/nar/gkm580
R. Rieder, K. Lang, D. Graber, and R. Micura*
Ligand-induced folding of the adenosine deaminase A-riboswitch and implications on riboswitch translational control
ChemBioChem 2007, 8, 896-902
doi: external page 10.1002/cbic.200700057
2006
M.D. Erlacher, K. Lang, B. Wotzel, R. Rieder, R. Micura* and N. Polacek*
Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2’-OH at A2451 of 23S rRNA
J. Am. Chem. Soc. 2006, 128, 4453-4459
doi: external page 10.1021/ja0588454
H. Moroder, C. Kreutz, K. Lang, A. Serganov, and R. Micura*
Synthesis, oxidation behavior, crystallization and structure of 2’-methylseleno guanosine containing RNAs
J. Am. Chem. Soc. 2006, 128, 9909-9918
doi: external page 10.1021/ja0621400
R. Micura*, C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, H. Moroder
Preparation of 2’-deoxy-2’-methylseleno-modified RNA
Current Protocols in Nucleic Acid Chemistry 2006, Wiley, C1.15.1 – C1.15.34
doi: external page 10.1002/0471142700.nc0115s27
2005
M.D. Erlacher, K. Lang, N. Shankaran, B. Wotzel, A. Hüttenhofer, R. Micura, A.S. Mankin and N. Polacek*
Chemical engineering of the peptidyl transferase center reveals an important role of the 2’-hydroxyl group of A2451
Nucleic Acids Res. 2005, 33, 1618-1627
doi: external page 10.1093/nar/gki308
C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, and R. Micura*
Syntheses of RNAs with up to 100 nucleotides containing site-specific 2’-Se-methyl labels for use in X-ray crystallography
J. Am. Chem. Soc. 2005, 127, 12035-12045
doi: external page 10.1021/ja051694k